ERC Funding!

Björn Högberg has been awarded a European Research Council Consolidators grant.

Publication in Nature

Read about our new approach to DNA-origami in this issue of Nature: here.

Publication in Angewandte Chemie

The polygonal meshes are now making very nice flat sheets! Read our new paper here.

Funding

Vetenskapsrådet (VR), The Swedish Foundation for Strategic research and the Knut and Alice Wallenberg foundation

Students wanted

We are looking to recruit master’s thesis students and interns that might be interested in doing a PhD in disciplines from biology to physics and computer science. Please contact Björn.

Contact

For any requests about the lab or this site, send your e-mail to Björn Högberg or call Björn on: +46 8 524 870 36. Our webpage on The Karolinska Institutets web can be found here.

 

Research Focus

The overarching effort in our lab is to develop new DNA-based methods and molecular tools for cell biology research.

Molecular tools for cell biology

By using DNA-origami, we are able to construct precise patterns of different molecules on a nanometer scale. Using these we can probe the effect the distance has on a number of cellular mechanisms. In this effort we use cell culture, superresolution microscopy, electron microscopy and next generation sequencing. We are also developing new (non-origami) DNA probes to detect splicing events or protein clustering in-situ.

Development of DNA self-assembly technology

A second part of the lab is focused on research on the basics of DNA self-assembly and DNA nanotechnology to improve their suitability for the above applications. Among other things we are developing a new design paradigm for DNA nanotechnology using a new type of triangulated meshes.

Synthetic biology for DNA nanotechnology

Lastly, a part of the lab develops synthetic biology/microbiology -methods to produce the building blocks we need for our nanostructures in bacteria. The ultimate goal is to engineer bacteria to mass produce through large scale cultures, all the components necessary for the DNA-origami/protein nanostructures.

 

Using DNA as a construction material

By using the method of DNA origami , we are able to design and fabricate nanoscale devices as if we were using macro-scale techniques. This video briefly introduces some of our applications.

 

Transmission Electron Microscope images of the completed DNA nanostructures from the video above. The scale bars are 20 nm.